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    Recombinant Human CD5 (hFc-Avi Tag)

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    Recombinant Human CD5 (hFc-Avi Tag) 

    產品信息

     

    產品名稱

    產品編號

    規格

    價格(元)

    Recombinant Human CD5 (hFc-Avi Tag)

    93117ES25

    25 μg

    1185

    93117ES60

    100 μg

    3385

    93117ES76

    500 μg

    11635

    93117ES80

    1 mg

    19985

     

    產品描述

     

    CD5, also known as Leu-1, Ly-1, and T1, is a 67 kDa transmembrane glycoprotein in the scavenger receptor superfamily. CD5 has been shown to interact homophilically, with CD72 on B cells, and with beta-glucan components of fungal cell walls. CD5 expression on developing thymocytes is positively regulated by signaling through the T cell antigen receptor (TCR) and is up?regulated on tolerized peripheral CD4+ cells. It inhibits TCR signaling and promotes T cell nonresponsiveness and survival. CD5 signaling inhibits the generation of regulatory T cells but promotes the development of Th17 cells. Within the B cell lineage, CD5 is expressed on B-1a cells, anergic B cells, and IL-10 producing regulatory B cells. Similarly to on T cells, it negatively regulates signaling through the B cell antigen receptor and supports peripheral B cell survival, anergy, and tolerance. B cells can produce an intracellularly-retained form of CD5 which lacks the signal peptide and a portion of the first SRCR domain. CD5 is also involved in the cellular entry of hepatitis C virus into T cells.

     

    產品性質

     

    別名

    CD5 molecule; CD5; LEU1; T1; CD5 antigen

    Uniprot No.

    P06127

    表達區間及表達系統

    Recombinant Human CD5 Protein is expressed from HEK293 Cells with hFc tag and Avi tag at the C-terminal. It contains Arg25-Asn371.

    分子量

    Approximately 67.1 kDa. Due to glycosylation, the protein migrates to 75-82 kDa based on Tris-Bis PAGE result.

    純度

    > 95% as determined by SDS-PAGE and HPLC.

    活性

    ELISA Data: Immobilized Human CD5 at 0.5μg/ml (100μl/Well) on the plate. Dose response curve for Biotinylated Anti-CD5 Antibody, hFc Tag with the EC50 19.6ng/ml determined by ELISA.

    內毒素

    1.0 EU per 1μg of the protein by the LAL method.

    制劑

    Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 5% trehalose is added as protectant before lyophilization.

    復溶

    Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/mL is recommended (usually we use 1 mg/mL solution for lyophilization). Dissolve the lyophilized protein in distilled water.

     

    運輸與保存方法

     

    冰袋運輸。-20-80存,一年有效期。

    復溶后,-20 -80°C,在未開封狀態下保存 3-6 個月。復溶后,2-8°C 保存 2-7 天。

    建議第一次使用時分裝存,避免反復凍融。


     

    注意事項

     

    1. 避免反復凍融。

    2. 為了您的安全和健康,請穿實驗服并戴一次性手套操作。

    3. 本產品僅作科研用途!

     

    產品數據


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    HB220809

    400-6111-883

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